Mast Cell Activation Syndrome is a spectrum of syndromes involving immune cells called mast cells. Mast cells are responsible for releasing chemicals like histamine, which are vital in defending the body against threats. In individuals with MCAS, these mast cells are overactive, releasing excessive amounts of chemicals in response to triggers that would not normally cause a reaction. 

- Food sensitivities
- Environmental allergens (e.g., pollen, dust, mold)
- Medications
- Temperature changes
- Stress

- Flushing
- Hives
- Swelling
- Low blood pressure, Dizziness or lightheadedness
-Tachycardia - fast heart rate
- Abdominal pain, diarrhea, or constipation.
- Wheezing, coughing, or shortness of breath.
- Fatigue
- Joint pain
- Headaches

Mast cells are present everywhere there is connective tissue and Hypermobile EDS is a connective tissue syndrome. The connective tissue abnormalities associated with hEDS may affect the behavior of mast cells. Many individuals with hEDS experience symptoms associated with MCAS and there is a symptom overlap between the conditions.

Please note at Hypermobile Natural Therapies often clients will come to us with a diagnosis of MCAS and either will not know they are hypermobile or will not have hypermobility. MCAS can occur for a variety of reasons, including post viral infections such as COVID.